Wow! This is a very interesting discussion. I've been on Effexor XR for about 2 years. Here is what I've noticed:

1. It did help the depression. I still get depressed at times, but not the feeling that I just want to cry over everything or not want to get out of bed in the morning.
2. I've noticed that if I don't take it at the same time every morning that I get terrible migraine-like headaches that are very hard to get rid of.
3. I've also gained weight, but I didn't realize it was the Effexor. I thought it was one antidepressant that didn't cause weight gain.
4. It is very hard to go off of. You have to do it gradually and go by the doctors instructions or you will have all kinds of mood swings and side effects.

It's hard to deal with depression because of the side effects of these antidepressants. My doctor said mine is a chemical imbalance in my brain. It's not because of any past problems. I had a happy family growing up.

Also, is unfounded guilt a side-effect of depression? I have a feeling of guilt almost all the time, even though I'm not doing anything wrong.

For example, if I don't spend enough time with my family or if I don't have a productive enough day, I feel guilty. That just adds to the depression.

Thanks for letting me unload!