Yeah, Smile. I take Tylenol. (Tylenol 3 works better - when I can get it) How often? That depends. In a (relatively) pain-free stretch I won't take anything at all. In a bad patch I'll take it everyday - even twice or three times a day - usually with aspirin. Why that way? Aspirin is faster but Tylenol lasts longer so if I use them together I get better results. Hope that helps. BTW, on a scale of 0-10, I won't take anything til the pain hits 4 or 5. 1 - 3 I just ignore. Oh, and I've had it for about 20 years.