The Soprano's incorporates the Catholic church into many of it's episodes and it is not always portrayed in a good light.

Brothers and Sisters is about a family where it seems that each member has his or her own particular views about many world topics and yet they manage to love and care about one another despite their individuality and beliefs.

Boston Legal touches on many varied topics and opinions in their court cases each week, including Wiccan beliefs, how transvestites are viewed by the public and political values from opposing sides.
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Where I've been lately