in the mental health outpatient program where I worked for 10 years was a 50 year old chronically depressed woman who said that she'd been changing her meds periodically, because they got to the point where they didn't work. Finally, her doctor said to her, and it sank in, that there might be a root cause for her depression, and that no medication could make that go away. She seemed kind of surprised to hear it, and kind of relieved also. It started her on a sort of quest. I think there's a very strong strain of thinking in our culture that there are "diseases" that have "cures" and that we don't have to exert any effort to relieve ourselves of these things.